1185239-75-1
Chemical Structure
Zimeldine-d6
- CAS No.: 1185239-75-1
- Formula:C16H11D6BrN2
- Molecular Weight:323.26
IUPAC Name: (E)-3-(4-bromophenyl)-N,N-bis(methyl-d3)-3-(pyridin-3-yl)prop-2-en-1-amine
InChIKey: OYPPVKRFBIWMSX-YXZLHESDSA-N
SMILES: C(=CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])(C1=CC=C(Br)C=C1)C=2C=CC=NC2
Biological Activity: Zimeldine-d6 is the deuterium labeled Zimeldine (HY-118835)[1]. Zimelidine is an orally active selective serotonin reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance[1][2][3][4].
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Zimeldine-d6 | Zimeldine-d6 is the deuterium labeled Zimeldine (HY-118835). Zimelidine is an orally active selective serotonin reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance. | |||||||||||||||||||||
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Zimelidine | Zimelidine is an orally active selective serotonin reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance. | |||||||||||||||||||||
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Keywords
