123714-50-1
123714-50-1
Chemical Structure
Acetyl-Calpastatin(184-210)(human)
- CAS No.: 123714-50-1
- Formula:C142H230N36O44S
- Molecular Weight:3177.63
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)[C@H]3N(CCC3)C([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@H](CO)NC([C@H](CCSC)NC([C@H]4N(CCC4)C([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Acetyl-Calpastatin(184-210)(human) | 98.57% | Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
TAT-N15 | TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ANT308 | ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
C3bot(154-182) | C3bot(154-182) is a C3 peptide enhances recovery from spinal cord injury by improving regenerative growth of descending fiber tracts. C3bot(154-182) represents a promising tool to foster axonal protection and/or repair, as well as functional recovery after traumatic CNS injury. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Calcineurin autoinhibitory peptide | 99.99% | Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
β-Endorphin, human | 98.94% | β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) | Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) (PBAN), a member of the PBAN/Pyrokinin neuropeptide family, characterized by a common amino acid sequence FXPRLamide motif in the C-terminus. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetyl-β-Endorphin (human) | Acetyl-β-Endorphin (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
VIPhyb | 99.82% | VIPhyb is a vasoactive intestinal polypeptide (VIP) receptor antagonist. VIPhyb can inhibit VIP signaling, increase T-cell immunity and downregulate PD1. VIPhyb can inhibit cancer cell proliferation. VIPhyb can reduce inflammatory cytokine expression. VIPhyb can enhance viral clearance. VIPhyb can be used for the researches of cancer, infection and inflammation and immunology, such as non-small cell lung cancer (NSCLC), cytomegalovirus infection and colitis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Calpastatin subdomain B | Calpastatin subdomain B is a biological active peptide. (inhibit calpain activity) | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
β-Endorphin (1-27) (human) | β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with Kis of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3. [Content Brief]
- [2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355. [Content Brief]
