12656-40-5
Chemical Structure
Althiomycin
Synonym(s): NSC 102809
- CAS No.: 12656-40-5
- Formula:C16H17N5O6S2
- Molecular Weight:439.47
IUPAC Name: N-(2-hydroxy-1-((S)-4-(4-methoxy-2-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl)-4,5-dihydrothiazol-2-yl)ethyl)-2-((E)-(hydroxyimino)methyl)thiazole-4-carboxamide
InChIKey: VQQNQKXWJMRPHT-GMLCBOFYSA-N
SMILES: O=C(C1=CSC(/C=N/O)=N1)NC(C2=N[C@@H](C(N3C(C=C(OC)C3)=O)=O)CS2)CO
Biological Activity: Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL.
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Althiomycin | Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL. | |||||||||||||||||||||
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