129281-28-3
Chemical Structure
SYA16263
- CAS No.: 129281-28-3
- Formula:C19H24FN3
- Molecular Weight:313.41
InChIKey: NSMCYUMPIGJKHV-UHFFFAOYSA-N
SMILES: FC(C=C1)=CC=C1CCCCN(CC2)CCN2C3=CC=CC=N3
Biological Activity: SYA16263 is a dopamine D2 receptor (D2R) and serotonin 1A receptor (5-HT1AR) ligand, with Ki values of 1.24 nM and 0.67 nM for D2R and 5-HT1AR, respectively. SYA16263 stabilizes the inactive conformation of D2R and 5-HT1AR via interactions with specific amino acid residues in their orthosteric binding pockets, thereby blocking downstream signal transduction. SYA16263 can be used in research related to schizophrenia and psychosis[1].
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SYA16263 | SYA16263 is a dopamine D2 receptor (D2R) and serotonin 1A receptor (5-HT1AR) ligand, with Ki values of 1.24 nM and 0.67 nM for D2R and 5-HT1AR, respectively. SYA16263 stabilizes the inactive conformation of D2R and 5-HT1AR via interactions with specific amino acid residues in their orthosteric binding pockets, thereby blocking downstream signal transduction. SYA16263 can be used in research related to schizophrenia and psychosis. | |||||||||||||||||||||
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Keywords
