129587-09-3
129587-09-3
Chemical Structure
Longilactone
- CAS 番号: 129587-09-3
- Formula:C19H26O7
- Molecular Weight:366.41
InChIKey: KBBRVTNGCNCUCX-LISBJPICSA-N
SMILES: C[C@]12[C@@]3([H])[C@@]4([C@@](C(C)=CC([C@H]4O)=O)([H])[C@H]([C@@]1([H])OC([C@@]2([H])[C@H]([C@H]([C@@H]3O)O)C)=O)O)C
Biological Activity: Longilactone is a quassinoid diterpenoid isolated from the roots of Eurycoma longifolia. Longilactone induces apoptosis in MCF-7 cells via the extrinsic caspase pathway, activating the cleavage of caspase-8, caspase-7 and PARP. Longilactone can be used in research related to breast cancer and human lung cancer[1][2][3].
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Longilactone | Longilactone is a quassinoid diterpenoid isolated from the roots of Eurycoma longifolia. Longilactone induces apoptosis in MCF-7 cells via the extrinsic caspase pathway, activating the cleavage of caspase-8, caspase-7 and PARP. Longilactone can be used in research related to breast cancer and human lung cancer. | |||||||||||||||||||||
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References
- [1]. Shamsul Muhamad, et al. Induction of apoptosis in MCF-7 via the Caspase pathway by longilactone from Eurycoma longifolia Jack. Research In Pharmaceutical Biotechnology Vol. 3(1), pp. 1-10, January 2011.ISSN 2141-2324
- [2]. Han YM, et al. Simultaneous quantitation of six major quassinoids in Tongkat Ali dietary supplements by liquid chromatography with tandem mass spectrometry. J Sep Sci. 2015 Jul;38(13):2260-6.
- [3]. Kuo PC, et al. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorganic & medicinal chemistry. 2004 Feb 01;12(3):537-44. [Content Brief]
