13252-13-6
Chemical Structure
Perfluoro(2-methyl-3-oxahexanoic) acid
Synonym(s): HFPO-DA
- CAS. Nr.: 13252-13-6
- Formula:C6HF11O3
- Molecular Weight:330.05
IUPAC Name: 2,3,3,3-tetrafluoro-2-(perfluoropropoxy)propanoic acid
InChIKey: CSEBNABAWMZWIF-UHFFFAOYSA-N
SMILES: O=C(O)C(OC(F)(F)C(F)(F)C(F)(F)F)(F)C(F)(F)F
Biological Activity: Perfluoro (2-methyl-3-oxahexanoic) acid (HFPO-DA) is an orally active PPARα agonist with an EC50 of 2.1 μM for human PPARα. Perfluoro (2-methyl-3-oxahexanoic) acid induces peroxisome proliferation and increases the levels of proinflammatory mediators. It impairs intestinal barrier function and disrupts cecal flora balance. Perfluoro (2-methyl-3-oxahexanoic) acid is applicable to research related to developmental toxicity, hepatotoxicity and intestinal toxicity[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Perfluoro(2-methyl-3-oxahexanoic) acid | 98.0% | Perfluoro (2-methyl-3-oxahexanoic) acid (HFPO-DA) is an orally active PPARα agonist with an EC50 of 2.1 μM for human PPARα. Perfluoro (2-methyl-3-oxahexanoic) acid induces peroxisome proliferation and increases the levels of proinflammatory mediators. It impairs intestinal barrier function and disrupts cecal flora balance. Perfluoro (2-methyl-3-oxahexanoic) acid is applicable to research related to developmental toxicity, hepatotoxicity and intestinal toxicity. | ||||||||||||||||||||
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References
- [1]. Heintz MM, et al. Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans. Toxicol Sci. 2023;192(1):15-29. [Content Brief]
- [2]. Wang Y, et al. Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos. Chemosphere. 2023;311(Pt 1):136999. [Content Brief]
- [3]. Xie X, et al. Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice. Environ Pollut. 2021;290:117934. [Content Brief]
