133399-65-2
Chemical Structure
3-MPPI
- CAS No.: 133399-65-2
- Formula:C23H25N5O3
- Molecular Weight:419.49
IUPAC Name: 3-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-1,5-dihydro-2H-pyrimido[5,4-b]indole-2,4(3H)-dione
InChIKey: AQASGOHUMGAWJJ-UHFFFAOYSA-N
SMILES: O=C1NC=2C=3C=CC=CC3NC2C(=O)N1CCN4CCN(C=5C=CC=CC5OC)CC4
Biological Activity: 3-MPPI is a GPCR ligand with high selectivity for α1-adrenergic receptor, with a Ki value of 0.21 nM for α1-adrenergic receptor and 50 nM for 5-HT1A receptor. 3-MPPI modulates the α1-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia[1].
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3-MPPI | 3-MPPI is a GPCR ligand with high selectivity for α1-adrenergic receptor, with a Ki value of 0.21 nM for α1-adrenergic receptor and 50 nM for 5-HT1A receptor. 3-MPPI modulates the α1-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia. | |||||||||||||||||||||
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Keywords
