133550-49-9
Chemical Structure
Tyrphostin AG 528
Synonym(s): Tyrphostin B66; AG 528
- CAS No.: 133550-49-9
- Formula:C18H14N2O3
- Molecular Weight:306.32
IUPAC Name: (E)-3-(3,4-dihydroxyphenyl)-2-(indoline-1-carbonyl)acrylonitrile
InChIKey: MYKCTDWWIWGLHW-NTEUORMPSA-N
SMILES: O=C(/C(C#N)=C/C1=CC=C(O)C(O)=C1)N2CCC3=CC=CC=C32
Biological Activity: Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC50s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2[1]. Tyrphostin AG 528 is also an anticancer agent[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tyrphostin AG 528 | 98.0% | Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC50s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2. Tyrphostin AG 528 is also an anticancer agent. | ||||||||||||||||||||
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- [1]. Naijue Zhu, et al. Tyrphostin Tumor Growth Inhibitors of EGFR and ErbB2 Tyrosine Kinase. J Chem Crystallogr. 2007, 37, 679–683.
- [2]. Sheikhi M, et al. Investigation of Adsorption Tyrphostin AG528 Anticancer Drug Upon the CNT(6,6-6) Nanotube: A DFT Study. Curr Mol Med. 2019;19(2):91-104. [Content Brief]
Keywords
