134332-63-1
134332-63-1
Chemical Structure
Phenoxan
- CAS No.: 134332-63-1
- Formula:C23H25NO4
- Molecular Weight:379.45
InChIKey: OFVMLCJEDYAOIB-FYWRMAATSA-N
SMILES: CCC1=C(C2=COC(CC/C(C)=C/C3=CC=CC=C3)=N2)OC(OC)=C(C1=O)C
Biological Activity: Phenoxan is an inhibitor of cytochrome b and NADH: ubiquinone oxidoreductase. It exerts anti-HIV, antifungal, and cytotoxic effects by inhibiting the electron transport chain, the activity of HIV-1 Reverse Transcriptase, and viral replication. Phenoxan can be used in studies of HIV-1 infection and fungal infections[1][2][3].
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Phenoxan | Phenoxan is an inhibitor of cytochrome b and NADH: ubiquinone oxidoreductase. It exerts anti-HIV, antifungal, and cytotoxic effects by inhibiting the electron transport chain, the activity of HIV-1 Reverse Transcriptase, and viral replication. Phenoxan can be used in studies of HIV-1 infection and fungal infections. | |||||||||||||||||||||
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References
- [1]. Kunze B, et al. Phenoxan, a new oxazole-pyrone from myxobacteria: production, antimicrobial activity and its inhibition of the electron transport in complex I of the respiratory chain. J Antibiot (Tokyo). 1992 Sep;45(9):1549-52.
- [2]. Jurkiewicz E, et al. Three New Potent HIV-1 Inhibitors from Myxobacteria. Antiviral Chemistry and Chemotherapy. 1992;3(4):189-193.
- [3]. Serebrianyĭ AM, et al. [Stimulated repopulation as a basis of antimutagenesis and the adaptive response in plants]. Genetika. 2002 Mar;38(3):340-6.
