1346617-34-2
Chemical Structure
Pretomanid-d4
- CAS No.: 1346617-34-2
- Formula:C14H8D4F3N3O5
- Molecular Weight:363.28
IUPAC Name: (S)-2-nitro-6-((4-(trifluoromethoxy)phenyl)methoxy-d2)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-5,5-d2
InChIKey: ZLHZLMOSPGACSZ-QXCFPOKCSA-N
SMILES: O=[N+](C1=CN2C(OC[C@H](C2([2H])[2H])OC([2H])([2H])C3=CC=C(C=C3)OC(F)(F)F)=N1)[O-]
Biological Activity: Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pretomanid-d4 | 99.83% | Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL. | ||||||||||||||||||||
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Pretomanid (Standard) | 99.72% | Pretomanid (Standard) is the analytical standard of Pretomanid. This product is intended for research and analytical applications. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL. | ||||||||||||||||||||
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Pretomanid-d5 | Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL. | |||||||||||||||||||||
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Pretomanid | 99.90% | Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL. | ||||||||||||||||||||
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-
Similarity Score 0.79
HY-124623DNDI-8219 -
Similarity Score 0.79
HY-129819(Rac)-DNDI-8219 -
Similarity Score 0.76
HY-12485RTBA-354 (Standard) -
Similarity Score 0.66
HY-W663179DNDI-VL-2098 -
Similarity Score 0.55
HY-184411TB-212 -
Similarity Score 0.54
HY-12485TBA-354 -
Similarity Score 0.52
HY-10846RDelamanid (Standard) -
Similarity Score 0.50
HY-156132DNDI-0690 -
Similarity Score 0.49
HY-10846SDelamanid-d4 -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Stover CK, et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature. 2000 Jun 22;405(6789):962-6. [Content Brief]
