Pretomanid-d4
Based on 1 Customer Validation
Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 1346617-34-2
- Formula: C14H8D4F3N3O5
- Molecular Weight:363.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1346617-34-2
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Unlabeled Cas 187235-37-6
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Appearance Solid
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Molecular Weight 363.28
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Formula C14H8D4F3N3O5
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Color White to light yellow
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SMILES
O=[N+](C1=CN2C(OC[C@H](C2([2H])[2H])OC([2H])([2H])C3=CC=C(C=C3)OC(F)(F)F)=N1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (344.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Stover CK, et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature. 2000 Jun 22;405(6789):962-6. [Content Brief]
[3]. Lenaerts AJ, et al. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301. [Content Brief]
[4]. Manjunatha UH, et al. Mycobacterium leprae is naturally resistant to PA-824. Antimicrob Agents Chemother. 2006 Oct;50(10):3350-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7527 mL | 13.7635 mL | 27.5270 mL | 68.8174 mL |
| 5 mM | 0.5505 mL | 2.7527 mL | 5.5054 mL | 13.7635 mL | |
| 10 mM | 0.2753 mL | 1.3763 mL | 2.7527 mL | 6.8817 mL | |
| 15 mM | 0.1835 mL | 0.9176 mL | 1.8351 mL | 4.5878 mL | |
| 20 mM | 0.1376 mL | 0.6882 mL | 1.3763 mL | 3.4409 mL | |
| 25 mM | 0.1101 mL | 0.5505 mL | 1.1011 mL | 2.7527 mL | |
| 30 mM | 0.0918 mL | 0.4588 mL | 0.9176 mL | 2.2939 mL | |
| 40 mM | 0.0688 mL | 0.3441 mL | 0.6882 mL | 1.7204 mL | |
| 50 mM | 0.0551 mL | 0.2753 mL | 0.5505 mL | 1.3763 mL | |
| 60 mM | 0.0459 mL | 0.2294 mL | 0.4588 mL | 1.1470 mL | |
| 80 mM | 0.0344 mL | 0.1720 mL | 0.3441 mL | 0.8602 mL | |
| 100 mM | 0.0275 mL | 0.1376 mL | 0.2753 mL | 0.6882 mL |
Pretomanid-d4 Related Classifications
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