1429515-59-2
1429515-59-2
Chemical Structure
FN-1501
Synonym(s): LT-171-861
- CAS No.: 1429515-59-2
- Formula:C22H25N9O
- Molecular Weight:431.49
IUPAC Name: 4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide
InChIKey: VXLAKHWYGRKCGI-UHFFFAOYSA-N
SMILES: O=C(C1=NNC=C1NC2=NC=NC3=C2C=CN3)NC4=CC=C(CN5CCN(C)CC5)C=C4
Biological Activity: FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FN-1501 | 98.72% | FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. | ||||||||||||||||||||
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FN-1501 (Standard) | ≥98% | FN-1501 (Standard) is the analytical standard of FN-1501 (HY-111361). This product is intended for research and analytical applications. FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-130980N-Desmethyl FN-1501 -
Similarity Score 0.84
HY-161709FLT3/CDKs ligand-1 -
Similarity Score 0.82
HY-130981FN-1501-propionic acid -
Similarity Score 0.57
HY-155594LT-540-717 -
Similarity Score 0.57
HY-161708PROTAC FLT3/CDKs degrader-1 -
Similarity Score 0.55
HY-130709PROTAC CDK2/9 Degrader-1 -
Similarity Score 0.54
HY-153473FLT3-IN-19 -
Similarity Score 0.54
HY-155513Syk-IN-8 -
Similarity Score 0.53
HY-15463Imatinib -
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