1446261-44-4
Chemical Structure
Pamiparib
Synonym(s): BGB-290
- CAS 番号: 1446261-44-4
- Formula:C16H15FN4O
- Molecular Weight:298.32
IUPAC Name: (R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one
InChIKey: DENYZIUJOTUUNY-MRXNPFEDSA-N
SMILES: O=C1NN=C2CN(CCC3)[C@@]3(C)C(N4)=C2C5=C4C=C(F)C=C51
Biological Activity: Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC50 values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. Pamiparib has potent PARP trapping, and capability to penetrate the brain, and can be used for the research of various cancers including the solid tumor[1][2].
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Pamiparib | 99.96% | Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC50 values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. Pamiparib has potent PARP trapping, and capability to penetrate the brain, and can be used for the research of various cancers including the solid tumor. | ||||||||||||||||||||
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Pamiparib (Standard) | ≥98% | Pamiparib (Standard) is the analytical standard of Pamiparib. This product is intended for research and analytical applications. Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC50 values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. Pamiparib has potent PARP trapping, and capability to penetrate the brain, and can be used for the research of various cancers including the solid tumor. | ||||||||||||||||||||
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Similarity Score 0.48
HY-156623Lerzeparib -
Similarity Score 0.45
HY-144642PARP-1-IN-1 -
Similarity Score 0.44
HY-10617BRucaparib hydrochloride -
Similarity Score 0.44
HY-10617ARucaparib -
Similarity Score 0.43
HY-10617AS1Rucaparib-d3 -
Similarity Score 0.43
HY-10617DRucaparib acetate -
Similarity Score 0.42
HY-111191ONO-2952 -
Similarity Score 0.42
HY-111191A(R)-ONO-2952 -
Similarity Score 0.42
HY-N2143Fumitremorgin C -
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References
- [1]. Changyou Zhou, et al. Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors. WO 2013097225 A1.
- [2]. Friedlander M, et al. Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial. Lancet Oncol. 2019 Sep;20(9):1306-1315. [Content Brief]
