1450666-97-3
Chemical Structure
MMV666810
- CAS No.: 1450666-97-3
- Formula:C23H21F3N4O2
- Molecular Weight:442.43
IUPAC Name: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-hydroxypiperidin-1-yl)methanone
InChIKey: FKDIWALLMXDOBS-UHFFFAOYSA-N
SMILES: O=C(N1CCC(O)CC1)C(C=C2)=CC=C2C3=CN=C(N)C(C4=CC=C(C(F)(F)F)C=C4)=N3
Biological Activity: MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
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MMV666810 | MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM). | |||||||||||||||||||||
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Keywords
