1464-33-1
Chemical Structure
4'-O-Methylpyridoxine
- CAS No.: 1464-33-1
- Formula:C9H13NO3
- Molecular Weight:183.20
IUPAC Name: 5-(hydroxymethyl)-4-(methoxymethyl)-2-methylpyridin-3-ol
InChIKey: SVINQHQHARVZFF-UHFFFAOYSA-N
SMILES: OCC1=C(COC)C(O)=C(C)N=C1
Biological Activity: 4'-O-Methylpyridoxine is an orally active antivitamin B6 compound found in Ginkgo biloba seeds and leaves. 4'-O-Methylpyridoxine inhibits pyridoxal kinase. 4'-O-Methylpyridoxine reduces brain pyridoxal-5'-phosphate (PLP) levels, decreases gamma-aminobutyric acid/glutamate (GABA/Glu) ratio. 4'-O-Methylpyridoxine increases plasma levels of pyridoxal-5'-phosphate and pyridoxal. 4'-O-Methylpyridoxine induces hyperactivity, convulsions, pathological tissue changes, organ damage in rodent brain and heart[1][2].
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4'-O-Methylpyridoxine | 99.92% | 4'-O-Methylpyridoxine is an orally active antivitamin B6 compound found in Ginkgo biloba seeds and leaves. 4'-O-Methylpyridoxine inhibits pyridoxal kinase. 4'-O-Methylpyridoxine reduces brain pyridoxal-5'-phosphate (PLP) levels, decreases gamma-aminobutyric acid/glutamate (GABA/Glu) ratio. 4'-O-Methylpyridoxine increases plasma levels of pyridoxal-5'-phosphate and pyridoxal. 4'-O-Methylpyridoxine induces hyperactivity, convulsions, pathological tissue changes, organ damage in rodent brain and heart. | ||||||||||||||||||||
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References
- [1]. Sado T, et al. Direct Evidence that 4'-O-methylpyridoxine Induces Hyperactivity and Convulsions due to Pyridoxal Phosphate Deficiency in the Brain[J]. THE SHINSHU MEDICAL JOURNAL, 2024, 72(3): 159-167.
- [2]. Zhu JP, et al. In vivo toxicity assessment of 4'-O-methylpyridoxine from Ginkgo biloba seeds: Growth, hematology, metabolism, and oxidative parameters. Toxicon. 2021;201:66-73. [Content Brief]
