147663-20-5
Chemical Structure
Azepexole hydrochloride
Synonym(s): B-HT 933 hydrochloride; Oxazoloazepin hydrochloride
- CAS No.: 147663-20-5
- Formula:C9H16ClN3O
- Molecular Weight:217.70
InChIKey: RISPXEICLQYFJX-UHFFFAOYSA-N
SMILES: CCN(CC1)CCC2=C1OC(N)=N2.Cl
Biological Activity: Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy[1][2].
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Azepexole hydrochloride | 99.89% | Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy. | ||||||||||||||||||||
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- [1]. Altamirano-Espinoza AH, et al. Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117(1):31-38. [Content Brief]
- [2]. Capey S. Azepexole[J]. 2007.Pharm: The Comprehensive Pharmacology Reference.
Keywords
