149654-41-1
149654-41-1
Chemical Structure
U92016A hydrochloride
- CAS No.: 149654-41-1
- Formula:C19H26ClN3
- Molecular Weight:331.88
IUPAC Name: (R)-8-(dipropylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile hydrochloride
InChIKey: XHLKAMFNZKKRFJ-PKLMIRHRSA-N
SMILES: CCCN([C@H]1CC(C2=C(C=C3)NC(C#N)=C2)=C3CC1)CCC.Cl
Biological Activity: U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity[1][2]. U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM)[2].
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U92016A hydrochloride | 99.9% | U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity. U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM). | ||||||||||||||||||||
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References
- [1]. A G Romero, et al. Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J Med Chem. 1993 Jul 23;36(15):2066-74. [Content Brief]
- [2]. R B McCall, et al. Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J Pharmacol Exp Ther. 1994 Nov;271(2):875-83. [Content Brief]
