153997-72-9
153997-72-9
Chemical Structure
ICP-103
- CAS No.: 153997-72-9
- Formula:C24H16N4O2
- Molecular Weight:392.41
SMILES: N#CCCN(C1=C2C(C(NC3=O)=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6
Biological Activity: ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC50 of 30 nM. ICP-103 is promising for research of cancers[1][2].
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ICP-103 | ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC50 of 30 nM. ICP-103 is promising for research of cancers. | |||||||||||||||||||||
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References
- [1]. Kleinschroth J, Hartenstein J, Rudolph C, et al. Novel indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5(1): 55-60.
- [2]. Roy S, Eastman A, Gribble G W. Synthesis of 7‐keto‐Gö6976 (ICP‐103)[J]. Synthetic communications, 2005, 35(4): 595-601.
