160399-35-9
Chemical Structure
AK 295
Synonym(s): CX 295
- CAS No.: 160399-35-9
- Formula:C26H40N4O6
- Molecular Weight:504.62
IUPAC Name: benzyl ((2S)-4-methyl-1-((1-((3-morpholinopropyl)amino)-1,2-dioxopentan-3-yl)amino)-1-oxopentan-2-yl)carbamate
InChIKey: TZVQRMYLYQNBOA-KEKNWZKVSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(NC(C(C(NCCCN1CCOCC1)=O)=O)CC)=O)OCC2=CC=CC=C2
Biological Activity: AK 295 (CX 295) is a selective calpain inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AK 295 | 99.0% | AK 295 (CX 295) is a selective calpain inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis. | ||||||||||||||||||||
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- [1]. Colak A, et al. Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats. Neurocirugia (Astur). 2009 Jun;20(3):245-54. [Content Brief]
- [2]. Bartus RT, et al. Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration. Stroke. 1994 Nov;25(11):2265-70. [Content Brief]
- [3]. DeBiasi RL, et al. Calpain inhibition protects against virus-induced apoptotic myocardial injury. J Virol. 2001 Jan;75(1):351-61. [Content Brief]
Keywords
