1628606-05-2
Chemical Structure
Vimseltinib
Synonym(s): DCC-3014
- CAS No.: 1628606-05-2
- Formula:C23H25N7O2
- Molecular Weight:431.49
IUPAC Name: 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one
InChIKey: TVGAHWWPABTBCX-UHFFFAOYSA-N
SMILES: O=C1N(C)C(NC(C)C)=NC=C1C2=NC(C)=C(OC3=CC(C4=CN(C)N=C4)=NC=C3)C=C2
Biological Activity: Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively[1]. Vimseltinib has certain oral bioavailability[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vimseltinib | 99.94% | Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively. Vimseltinib has certain oral bioavailability. | ||||||||||||||||||||
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- [1]. Yumi Ahn, et al. 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145025A2.
- [2]. Kisielewska K, et al. An evaluation of vimseltinib for treatment of tenosynovial giant cell tumors. Expert Rev Anticancer Ther. 2025 Apr;25(4):327-335. [Content Brief]
Keywords
