1644159-87-4
Chemical Structure
TT-1
- CAS No.: 1644159-87-4
- Formula:C57H108N14O14
- Molecular Weight:1213.55
InChIKey: ZQERJPCNIFWPST-SCPHLJMSSA-N
SMILES: O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: TT-1 is an acetylcholinesterase inhibitor (human IC50 = 18.6 μM) and an amyloid β (1-42) aggregation inhibitor with antioxidant capacity, and it exerts antitumor effects by downregulating ADAM10 expression, upregulating MICA, and activating the intrinsic mitochondrial apoptosis pathway. TT-1 can be used for research on Alzheimer's disease, liver cancer, and epilepsy[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TT-1 | TT-1 is an acetylcholinesterase inhibitor (human IC50 = 18.6 μM) and an amyloid β (1-42) aggregation inhibitor with antioxidant capacity, and it exerts antitumor effects by downregulating ADAM10 expression, upregulating MICA, and activating the intrinsic mitochondrial apoptosis pathway. TT-1 can be used for research on Alzheimer's disease, liver cancer, and epilepsy. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Chen LG, et al. Hydrolysable Tannins Exhibit Acetylcholinesterase Inhibitory and Anti-Glycation Activities In Vitro and Learning and Memory Function Improvements in Scopolamine-Induced Amnesiac Mice. Biomedicines. 2021 Aug 23;9(8):1066. [Content Brief]
- [2]. Wan LL, et al. Anti-hepatocarcinoma activity of TT-1, an analog of melittin, combined with interferon-α via promoting the interaction of NKG2D and MICA. Journal of Zhejiang University. Science. B. 2017 Jun;18(6):522-531.
- [3]. Setayesh-Mehr Z. Upregulation of Bax, TNF-α and down-regulation of Bcl-2 in liver cancer cells treated with HL-7 and HL-10 peptides. Biologia. 2021 Sep;76(9):2735-43.
- [4]. Liang F, et al. Zif268 and Fos-like immunoreactivity in tetanus toxin-induced epilepsy: reciprocal changes in the epileptic focus and the surround. Brain research. 1997 Dec 19;778(2):281-92.
