1775-97-9
1775-97-9
Chemical Structure
Flavokawain B
Synonym(s): Flavokavain B
- CAS No.: 1775-97-9
- Formula:C17H16O4
- Molecular Weight:284.31
IUPAC Name: (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
InChIKey: QKQLSQLKXBHUSO-CMDGGOBGSA-N
SMILES: O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2
Biological Activity: Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates Bcl-2 with concomitant increase in Bax level. Flavokawain B inhibits NF-κB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation[1][2][3][4][5][6][7][8][9][10][11][12][13].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flavokawain B | 99.99% | Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates Bcl-2 with concomitant increase in Bax level. Flavokawain B inhibits NF-κB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation. | ||||||||||||||||||||
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Flavokawain B (Standard) | ≥98% | Flavokawain B (Standard) is the analytical standard of Flavokawain B. This product is intended for research and analytical applications. Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations. | ||||||||||||||||||||
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FKB04 | 99.98% | FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research. | ||||||||||||||||||||
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Cardamonin | 99.80% | Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities. | ||||||||||||||||||||
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(E)-Cardamonin (Standard) | ≥98% | (E)-Cardamonin (Standard) is the analytical standard of (E)-Cardamonin. This product is intended for research and analytical applications. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. | ||||||||||||||||||||
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(E/Z)-Flavokawain B | (E/Z)-Flavokawain B (compound 4) is a chalcone and nitric oxide production inhibitor with an IC50 of 6.8 μM.(E/Z)-Flavokawain B can be found in the aerial parts of Sarcandra glabra.(E/Z)-Flavokawain B inhibits lipopolysaccharide-induced nitric oxide production. | |||||||||||||||||||||
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Flavokawain A (Standard) | ≥98% | Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer. | ||||||||||||||||||||
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Flavokawain C (Standard) | ≥98% | Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC50 of 12.75 μM for HCT 116 cells. | ||||||||||||||||||||
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Pinostrobin chalcone (Standard) | ≥98% | Pinostrobin chalcone (Standard) is the analytical standard of Pinostrobin chalcone (HY-N3057). This product is intended for research and analytical applications. Pinostrobin chalcone is a chalcone found in Boesenbergia rotunda and Alpinia mutica. Pinostrobin chalcone exhibits cytotoxicity against various cancer cells. Pinostrobin chalcone is predicted to bind to the JAK active site, forming a hydrogen bond with Asn859 and hydrophobic interactions with aromatic residues. Pinostrobin chalcone can be used in research related to breast cancer, colon cancer, cervical cancer, and epidermoid carcinoma. | ||||||||||||||||||||
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(E)-Flavokawain A (Standard) | ≥98% | (E)-Flavokawain A (Standard) is the analytical standard of (E)-Flavokawain A. This product is intended for research and analytical applications. (E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. | ||||||||||||||||||||
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Flavokawin C | 99.67% | Flavokawin C is a natural compound with antioxidative and cytotoxicity. | ||||||||||||||||||||
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(E)-2′,4′-Dimethoxychalcone | (E)-2′,4′-Dimethoxychalcone is a flavonoid compound. | |||||||||||||||||||||
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References
- [1]. Rossette MC, et al. The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. Phytother Res. 2017 Oct;31(10):1607-1613. [Content Brief]
- [2]. Li X, et al. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25. [Content Brief]
- [3]. Zhao M, et al. The kava chalcone flavokawain B exerts inhibitory activity and synergizes with BCL-2 inhibition in malignant B-cell lymphoma. Phytomedicine. 2023 Nov;120:155074. [Content Brief]
- [4]. Lin CT, et al. Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. J Agric Food Chem. 2009 Jul 22;57(14):6060-5. [Content Brief]
- [5]. Lin E, et al. Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. J Nutr Biochem. 2012 Apr;23(4):368-78. [Content Brief]
- [6]. Sakai T, et al. Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res. 2012 Jul;30(7):1045-50. [Content Brief]
- [7]. Ji T, et al. Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. Mol Cancer. 2013 Jun 10;12:55. [Content Brief]
- [8]. Hseu YC, et al. The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. J Agric Food Chem. 2012 Mar 7;60(9):2385-97. [Content Brief]
- [9]. Eskander RN, et al. Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. J Obstet Gynaecol Res. 2012 Aug;38(8):1086-94. [Content Brief]
- [10]. Chen Y, et al. Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in inflammatory bowel disease by targeting TLR2. Toxicol Appl Pharmacol. 2024 May;486:116922. [Content Brief]
- [11]. Zhou P, et al. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. FASEB J. 2010 Dec;24(12):4722-32. [Content Brief]
- [12]. Luo W, et al. Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2. Acta Pharmacol Sin. 2022 Jul;43(7):1758-1768. [Content Brief]
- [13]. Son JH, et al. Flavokawain B Inhibits Growth of Cholangiocarcinoma Cells by Suppressing the Akt Pathway. In Vivo. 2023 May-Jun;37(3):1077-1084. [Content Brief]
