1782102-85-5
Chemical Structure
GPR119 agonist 5
- CAS 番号: 1782102-85-5
- Formula:C30H40F2N4O4
- Molecular Weight:558.66
InChIKey: LXRUDSRTBHXMKW-MNNSJKJDSA-N
SMILES: O=C(C1=C(C=C(C2=CC=C(C=N2)OCC3CCN(CC3)CC(CC)(F)CC)C=C1)F)N4[C@@](C)(C[C@H](C4)O)C(N)=O
Biological Activity: GPR119 agonist 5 is an orally active GPR119 agonist with EC50=12.6 nM. GPR119 agonist 5 activates the Gs-cAMP signaling pathway and promotes GLP‑1, GIP, and glucose-dependent insulin secretion. GPR119 agonist 5 lowers blood glucose and increases plasma insulin and glucagon-like peptide levels in mice, and improves glycemic control and reduces glycated hemoglobin in diabetic rats. GPR119 agonist 5 can be used for research on type 2 diabetes[1].
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GPR119 agonist 5 | GPR119 agonist 5 is an orally active GPR119 agonist with EC50=12.6 nM. GPR119 agonist 5 activates the Gs-cAMP signaling pathway and promotes GLP‑1, GIP, and glucose-dependent insulin secretion. GPR119 agonist 5 lowers blood glucose and increases plasma insulin and glucagon-like peptide levels in mice, and improves glycemic control and reduces glycated hemoglobin in diabetic rats. GPR119 agonist 5 can be used for research on type 2 diabetes. | |||||||||||||||||||||
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