1816331-64-2
1816331-64-2
Chemical Structure
GSK990
- CAS No.: 1816331-64-2
- Formula:C23H23N7O2
- Molecular Weight:429.47
IUPAC Name: 1-((1H-imidazol-4-yl)methyl)-5-(1H-pyrrole-2-carbonyl)-N-(m-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide
InChIKey: PYCSPHYSYJHUKG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C)=C1)C2=NN(C3=C2CN(CC3)C(C4=CC=CN4)=O)CC5=CNC=N5
Biological Activity: GSK990 is an inactive mutant IDH1 inhibitor with no significant inhibitory activity against wild-type or mutant IDH1/IDH2 enzymes. In experiments, GSK990 can serve as an inactive negative control for the IDH1 inhibitor GSK321 (HY-18948). GSK990 is applicable to the research of acute myeloid leukemia[1].
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GSK990 | GSK990 is an inactive mutant IDH1 inhibitor with no significant inhibitory activity against wild-type or mutant IDH1/IDH2 enzymes. In experiments, GSK990 can serve as an inactive negative control for the IDH1 inhibitor GSK321 (HY-18948). GSK990 is applicable to the research of acute myeloid leukemia. | |||||||||||||||||||||
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