182153-96-4
182153-96-4
Chemical Structure
BIM-23190
- CAS. Nr.: 182153-96-4
- Formula:C57H79N13O12S2
- Molecular Weight:1202.45
InChIKey: YIGPOHXLINPVGT-CVGVOFIUSA-N
SMILES: O=C(N[C@H](C(N[C@H](C(N1)=O)CC)=O)CCCCN)[C@H](NC([C@@H](NC([C@H](CSSC[C@H]1C(N[C@H](C(N)=O)[C@H](O)C)=O)NC([C@H](NC(CN(CC2)CCN2CCO)=O)CC3=CC=CC=C3)=O)=O)CC(C=C4)=CC=C4O)=O)CC5=CNC6=CC=CC=C56
Biological Activity: BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly[1][3].
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BIM-23190 | BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly. | |||||||||||||||||||||
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References
- [1]. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92. [Content Brief]
- [3]. T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104. [Content Brief]
