187665-65-2
187665-65-2
Chemical Structure
PNU-142633
- CAS No.: 187665-65-2
- Formula:C24H30N4O3
- Molecular Weight:422.52
IUPAC Name: (S)-1-(2-(4-(4-carbamoylphenyl)piperazin-1-yl)ethyl)-N-methylisochromane-6-carboxamide
InChIKey: PNTVCCRNJOGKGA-QFIPXVFZSA-N
SMILES: O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(C(N)=O)C=C4)CC3)=C1)NC
Biological Activity: PNU-142633 is a high affinity, selective and orally active 5-HT1D receptor agonist with Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively. PNU-142633 has anti-migraine efficacy[1][2].
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PNU-142633 | 98.6% | PNU-142633 is a high affinity, selective and orally active 5-HT1D receptor agonist with Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively. PNU-142633 has anti-migraine efficacy. | ||||||||||||||||||||
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References
- [1]. McCall RB, et al. Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia. 2002 Dec;22(10):799-806. [Content Brief]
- [2]. Gomez-Mancilla B, et al. Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine. Cephalalgia. 2001 Sep;21(7):727-32. [Content Brief]
Keywords
