2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. PNU109291

PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

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PNU109291 Chemical Structure

PNU109291 Chemical Structure

CAS No. : 187665-60-7

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Description

PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].

In Vivo

PNU109291 (0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg; s.c.) reduces dural plasma extravasation evoked by trigeminal ganglion stimulation in pigs[1].
PNU109291 (3 µM) inhibited evoked EPSCs (excitatory postsynaptic currents) in Freund's adjuvant (CFA) but not saline-injected rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-500g, male Hartley guinea pigs[1]
Dosage: 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg
Administration: S.c.; 60 min before electrical stimulation
Result: Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg.
Molecular Weight

409.52

Formula

C24H31N3O3
CAS No.
SMILES

O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(OC)C=C4)CC3)=C1)NC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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PNU109291 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU109291187665-60-7PNU 109291PNU-1092915-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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