1982372-88-2
1982372-88-2
Chemical Structure
A-196
- CAS No.: 1982372-88-2
- Formula:C18H16Cl2N4
- Molecular Weight:359.25
IUPAC Name: 6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine
InChIKey: ABGOSOMRWSYAOB-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1
Biological Activity: A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A-196 | 98.76% | A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity. | ||||||||||||||||||||
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A-196 (Standard) | ≥98% | A-196 (Standard) is the analytical standard of A-196 (HY-100201). This product is intended for research and analytical applications. A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.57
HY-19184MKC-963 -
Similarity Score 0.57
HY-160545NLRP3-IN-31 -
Similarity Score 0.56
HY-153554NLRP3-IN-18 -
Similarity Score 0.53
HY-177128Sebrinoflast -
Similarity Score 0.52
HY-165360JJ1 -
Similarity Score 0.51
HY-163885SSZ -
Similarity Score 0.51
HY-148187NLRP3-IN-11 -
Similarity Score 0.50
HY-128142PKC/PKD-IN-1 -
Similarity Score 0.50
HY-100933MY-5445 -
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