20012-08-2
20012-08-2
Chemical Structure
Trepipam
Synonym(s): Trimopam; SCH-12679
- CAS No.: 20012-08-2
- Formula:C19H23NO2
- Molecular Weight:297.39
IUPAC Name: 7,8-dimethoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
InChIKey: ICPHJSKVAZMKIV-UHFFFAOYSA-N
SMILES: CN1CC(C2=CC(OC)=C(C=C2CC1)OC)C3=CC=CC=C3
Biological Activity: Trepipam (Trimopam; SCH-12679) is a D1-dopamine receptor antagonist. Trepipam can reduce the self-injurious behavior in 6-OHDA-lesioned rats. Trepipam can be used in the research of epilepsy and anxiety neurosis[1][2][3].
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Trepipam | Trepipam (Trimopam; SCH-12679) is a D1-dopamine receptor antagonist. Trepipam can reduce the self-injurious behavior in 6-OHDA-lesioned rats. Trepipam can be used in the research of epilepsy and anxiety neurosis. | |||||||||||||||||||||
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References
- [1]. Breese GR, et al. Pharmacological evaluation of SCH-12679: evidence for an in vivo antagonism of D1-dopamine receptors. J Pharmacol Exp Ther. 1990 Feb;252(2):558-67. [Content Brief]
- [2]. LaPierre Y D. Effectiveness of SCH 12679, a benzazepine, in the treatment of anxiety neurosis[J]. Current Therapeutic Research, 1978.
- [3]. Lapierre YD, et al. Pharmacologic management of aggressivity and self-mutilation in the mentally retarded. Psychiatr Clin North Am. 1986 Dec;9(4):745-54. [Content Brief]
