2091883-59-7
Chemical Structure
Dyrk1A-IN-4
- CAS No.: 2091883-59-7
- Formula:C14H13F3N6
- Molecular Weight:322.29
IUPAC Name: 4-(2-methyl-3-(2,2,2-trifluoroethyl)-3H-imidazo[4,5-b]pyridin-5-yl)pyridine-2,6-diamine
InChIKey: QHTJZFWEQYRYQE-UHFFFAOYSA-N
SMILES: FC(F)(CN1C2=C(N=C1C)C=CC(C3=CC(N)=NC(N)=C3)=N2)F
Biological Activity: Dyrk1A-IN-4 is a potent and orally active Dyrk1A inhibitor. Dyrk1A-IN-4 exhibits IC50s against DYRK1A and DYRK2 of 2 nM and 6 nM. Dyrk1A-IN-4 exhibits the inhibition of the DYRK1A pSer520 autophosphorylation in U2OS cells with an IC50 of 28 nM. Dyrk1A-IN-4 can be used for the studies of ovarian adenocarcinoma, neuroblastoma and cervical squamous cell carcinoma[1].
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Dyrk1A-IN-4 | 99.30% | Dyrk1A-IN-4 is a potent and orally active Dyrk1A inhibitor. Dyrk1A-IN-4 exhibits IC50s against DYRK1A and DYRK2 of 2 nM and 6 nM. Dyrk1A-IN-4 exhibits the inhibition of the DYRK1A pSer520 autophosphorylation in U2OS cells with an IC50 of 28 nM. Dyrk1A-IN-4 can be used for the studies of ovarian adenocarcinoma, neuroblastoma and cervical squamous cell carcinoma. | ||||||||||||||||||||
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Keywords
