2101765-83-5
Chemical Structure
DRI-C25441
- CAS No.: 2101765-83-5
- Formula:C31H21N3O6
- Molecular Weight:531.51
IUPAC Name: 4-(4'-(4-nitrobenzamido)-[1,1'-biphenyl]-4-carboxamido)-1-naphthoic acid
InChIKey: LZHHABGKCSZVBE-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=CC=CC2=C(NC(C3=CC=C(C4=CC=C(NC(C5=CC=C([N+]([O-])=O)C=C5)=O)C=C4)C=C3)=O)C=C1)O
Biological Activity: DRI-C25441 is a potent blocker of CD40 and CD40L interaction, with an IC50 of 0.36 μM. DRI-C25441 can inhibit the immune response induced by alloantigen. can inhibit CD40L induced activation of NF-κB signaling pathway. DRI-C25441 commonly is used in research on immune conditions [1][2].
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DRI-C25441 | 98.67% | DRI-C25441 is a potent blocker of CD40 and CD40L interaction, with an IC50 of 0.36 μM. DRI-C25441 can inhibit the immune response induced by alloantigen. can inhibit CD40L induced activation of NF-κB signaling pathway. DRI-C25441 commonly is used in research on immune conditions . | ||||||||||||||||||||
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- [1]. Lu H, et, al. Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials. Signal Transduct Target Ther. 2020 Sep 23;5(1):213. [Content Brief]
- [2]. Chen J, et al. Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction. J Med Chem. 2017 Nov 9;60(21):8906-8922. [Content Brief]
Keywords
