2137030-98-7
2137030-98-7
Chemical Structure
Ensartinib dihydrochloride
Synonym(s): X-396 dihydrochloride
- CAS No.: 2137030-98-7
- Formula:C26H29Cl4FN6O3
- Molecular Weight:634.36
IUPAC Name: 6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((3R,5S)-3,5-dimethylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide dihydrochloride
InChIKey: IERUINQRGJAECT-ISUJJMBGSA-N
SMILES: O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)C=C3.Cl.Cl
Biological Activity: Ensartinib dihydrochloride (X-396 dihydrochloride) is a BBB-permeable and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ensartinib dihydrochloride | 99.73% | Ensartinib dihydrochloride (X-396 dihydrochloride) is a BBB-permeable and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. | ||||||||||||||||||||
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Ensartinib dihydrochloride (Standard) | ≥98% | Ensartinib dihydrochloride (Standard) is the analytical standard of Ensartinib dihydrochloride (HY-103714A). This product is intended for research and analytical applications. Ensartinib dihydrochloride (X-396 dihydrochloride) is a BBB-permeable and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-103714Ensartinib -
Similarity Score 0.82
HY-16590X-376 -
Similarity Score 0.68
HY-165284CM-118 -
Similarity Score 0.52
HY-50878BCrizotinib acetate -
Similarity Score 0.51
HY-133202-Keto Crizotinib -
Similarity Score 0.51
HY-50878ACrizotinib hydrochloride -
Similarity Score 0.50
HY-161179TRK-IN-27 -
Similarity Score 0.50
HY-120387SMU-B -
Similarity Score 0.50
HY-100549(S)-Crizotinib -
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