2140-76-3
2140-76-3
Chemical Structure
2′-O-Methyluridine
- CAS No.: 2140-76-3
- Formula:C10H14N2O6
- Molecular Weight:258.23
IUPAC Name: 1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: SXUXMRMBWZCMEN-ZOQUXTDFSA-N
SMILES: O[C@H]1[C@@H](OC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1CO
Biological Activity: 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2′-O-Methyluridine | 99.92% | 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer. | ||||||||||||||||||||
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2′-O-Methyluridine (Standard) | 99.65% | 2′-O-Methyluridine (Standard) is the analytical standard of 2′-O-Methyluridine (HY-W001824). This product is intended for research and analytical applications. 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer. | ||||||||||||||||||||
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2′-O-Methyluridine-d3 | 99.30% | 2′-O-Methyluridine-d3 is deuterium labeled 2′-O-Methyluridine (HY-W011824).2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer. | ||||||||||||||||||||
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2’-O-Methyl-4-thiouridine | 99.38% | 2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||||||||||||||||||||
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1-(β-D-Xylofuranosyl)uracil | 1-(β-D-Xylofuranosyl)uracil is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents. | |||||||||||||||||||||
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2'-O-Propargyluridine | 2'-O-Propargyluridine is a monomeric raw material that can be used for nucleic acid synthesis. | |||||||||||||||||||||
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Uridine-13C | 99.82% | Uridine-13C is the 13C labeled Uridine. | ||||||||||||||||||||
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Uridine-13C5 | 99.90% | Uridine-13C5 (β-Uridine-13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond. | ||||||||||||||||||||
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1-beta-D-Arabinofuranosyluracil (Standard) | 99.91% | 1-beta-D-Arabinofuranosyluracil (Standard) is the analytical standard of 1-beta-D-Arabinofuranosyluracil. This product is intended for research and analytical applications. 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells. | ||||||||||||||||||||
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L-Uridine | 99.81% | L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases. | ||||||||||||||||||||
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2'-O-(2-Methoxyethyl)-uridine | 99.46% | 2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development. | ||||||||||||||||||||
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3’-O-Methyluridine | 3’-O-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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Uridine-13C9, 15N2 | 99.80% | Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is 13C and 15N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond. | ||||||||||||||||||||
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References
- [1]. Aučynaitė A, et al. Identification of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries. Molecules. 2018;23(11):2904. Published 2018 Nov 7. [Content Brief]
- [2]. Kuchino, Y., et al., (1985). Tetrahymena thermophila glutamine tRNA and its gene that corresponds to UAA termination codon. Proceedings of the National Academy of Sciences of the United States of America, 82(14), 4758–4762. [Content Brief]
- [3]. Judge, A. D., et al., (2006). Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 13(3), 494–505. [Content Brief]
- [4]. Fang, Z., et al., (2021). Mass Spectrometry-Based Targeted Serum Monomethylated Ribonucleosides Profiling for Early Detection of Breast Cancer. Frontiers in molecular biosciences, 8, 741603. [Content Brief]
