2140-76-3
2140-76-3
Chemical Structure
2′-O-Methyluridine
- CAS No.: 2140-76-3
- Formula:C10H14N2O6
- Molecular Weight:258.23
IUPAC Name: 1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: SXUXMRMBWZCMEN-ZOQUXTDFSA-N
SMILES: O[C@H]1[C@@H](OC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1CO
Biological Activity: 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer[1][2][3][4].
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2′-O-Methyluridine | 99.92% | 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer. | ||||||||||||||||||||
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2′-O-Methyluridine (Standard) | 99.65% | 2′-O-Methyluridine (Standard) is the analytical standard of 2′-O-Methyluridine (HY-W001824). This product is intended for research and analytical applications. 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer. | ||||||||||||||||||||
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2′-O-Methyluridine-d3 | 99.19% | 2′-O-Methyluridine-d3 is deuterium labeled 2′-O-Methyluridine (HY-W011824).2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer. | ||||||||||||||||||||
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References
- [1]. Aučynaitė A, et al. Identification of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries. Molecules. 2018;23(11):2904. Published 2018 Nov 7. [Content Brief]
- [2]. Kuchino, Y., et al., (1985). Tetrahymena thermophila glutamine tRNA and its gene that corresponds to UAA termination codon. Proceedings of the National Academy of Sciences of the United States of America, 82(14), 4758–4762. [Content Brief]
- [3]. Judge, A. D., et al., (2006). Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 13(3), 494–505. [Content Brief]
- [4]. Fang, Z., et al., (2021). Mass Spectrometry-Based Targeted Serum Monomethylated Ribonucleosides Profiling for Early Detection of Breast Cancer. Frontiers in molecular biosciences, 8, 741603. [Content Brief]
