2153563-36-9
Chemical Structure
C14-306
- CAS. Nr.: 2153563-36-9
- Formula:C63H131N3O4
- Molecular Weight:994.76
IUPAC Name: 1,1',1'',1'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(tetradecan-2-ol)
InChIKey: QMQSOHXJGZYDSS-UHFFFAOYSA-N
SMILES: OC(CN(CCCN(C)CCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCCCCCCCCCCC
Biological Activity: C14-306 is an ionizable lipid with a linear 306 amine core and a C14 alkyl tail. C14-306 enhances brain transfection efficiency. Lipid nanoparticles (LNP) formulated with C14-306 promote mRNA delivery, increase neuronal transfection rate, and facilitate Cre-mediated recombination in the brain, while reducing off-target expression in the liver[1][2].
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C14-306 | C14-306 is an ionizable lipid with a linear 306 amine core and a C14 alkyl tail. C14-306 enhances brain transfection efficiency. Lipid nanoparticles (LNP) formulated with C14-306 promote mRNA delivery, increase neuronal transfection rate, and facilitate Cre-mediated recombination in the brain, while reducing off-target expression in the liver. | |||||||||||||||||||||
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- [1]. Han EL, et al. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS nano. 2026 Feb 03;20(4):3807-3820. [Content Brief]
- [2]. Bhunia S M, Bhattacharjee A, Saha P, et al. Lipid Nanoparticles for Overcoming Biological Barriers to mRNA Delivery to the Brain[J].
Keywords