21668-77-9
Chemical Structure
Eprodisate (70% in water)
- CAS No.: 21668-77-9
- Formula:C3H8O6S2
- Molecular Weight:204.22
IUPAC Name: propane-1,3-disulfonic acid
InChIKey: MGNVWUDMMXZUDI-UHFFFAOYSA-N
SMILES: O=S(CCCS(=O)(O)=O)(O)=O
Biological Activity: Eprodisate (70% in water) is an amyloid inhibitor that interferes with the interaction between amyloidogenic proteins and glycosaminoglycans, thereby inhibiting the aggregation of amyloid fibrils and the deposition of fibrils in tissues. Eprodisate (70% in water) slows the progression of renal disease associated with AA amyloidosis and may be useful for other types of amyloidosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Eprodisate (70% in water) | 98.0% | Eprodisate (70% in water) is an amyloid inhibitor that interferes with the interaction between amyloidogenic proteins and glycosaminoglycans, thereby inhibiting the aggregation of amyloid fibrils and the deposition of fibrils in tissues. Eprodisate (70% in water) slows the progression of renal disease associated with AA amyloidosis and may be useful for other types of amyloidosis. | ||||||||||||||||||||
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- [1]. Dember LM, et al. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2349-60. [Content Brief]
- [2]. Manenti L, et al. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9(12):2175-80. [Content Brief]
- [3]. Quaranta DV, et al. Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation. J Pharmacol Exp Ther. 2023 Jan;384(1):205-223. [Content Brief]
Keywords
