2173389-57-4
Chemical Structure
Zilurgisertib
Synonym(s): INCB-000928; NBU-928
- CAS No.: 2173389-57-4
- Formula:C30H38N4O3
- Molecular Weight:502.65
IUPAC Name: 2-amino-N-(4-hydroxybicyclo[2.2.2]octan-1-yl)-5-(4-((1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl)phenyl)nicotinamide
InChIKey: KPRPFTOLWQQUAV-OCVAFRRMSA-N
SMILES: O=C(C1=CC(C2=CC=C(C=C2)[C@]3(CN(C4CCOCC4)C5)[C@]5([H])C3)=CN=C1N)NC(CC6)(CC7)CCC67O
Biological Activity: Zilurgisertib (INCB-000928; NBU-928) is a selective ALK2 inhibitor with an IC50 value of 15 nM. Zilurgisertib inhibits SMAD1/5 phosphorylation with an IC50 value of 63 nM. Zilurgisertib inhibits hepcidin production and improve anemia. Zilurgisertib can be used in melanoma research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zilurgisertib | 98.25% | Zilurgisertib (INCB-000928; NBU-928) is a selective ALK2 inhibitor with an IC50 value of 15 nM. Zilurgisertib inhibits SMAD1/5 phosphorylation with an IC50 value of 63 nM. Zilurgisertib inhibits hepcidin production and improve anemia. Zilurgisertib can be used in melanoma research. | ||||||||||||||||||||
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References
- [1]. Li J, et al. Preparation of aminopyridine derivatives and their use as selective ALK-2 inhibitors. WO2018014829 A1.
- [2]. Stubbs M C, et al. ALK2 and JAK2 inhibition for improved treatment of anemia in myelofibrosis patients: Preclinical profile of an ALK2 inhibitor Zilurgisertib in combination with Ruxolitinib. Blood, 2023, 142: 1789.
