PRMT5-IN-48
PRMT5-IN-48 (compound D3) is an orally effective PRMT5 inhibitor (IC50=20.7 nM) with anticancer activity. PRMT5-IN-48 can inhibit the growth of various cancer cells, induce apoptosis (apoptosis), and arrest the cell cycle at the G0/G1 phase. PRMT5-IN-48 can be used for non-Hodgkin lymphoma (NHL) research.
For research use only. We do not sell to patients.
- CAS No.: 2640287-77-8
- Formula: C30H37N5O3
- Molecular Weight:515.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
PRMT5[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-468 | IC50 |
7.4 nM
Compound: 24
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Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay
Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay
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[PMID: 37366223] |
| NCI-H358 | IC50 |
5 nM
Compound: 24
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Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay
Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay
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[PMID: 37366223] |
| Z-138 | IC50 |
2.2 nM
Compound: 24
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Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay
Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay
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[PMID: 37366223] |
| Species | Dose | Route | Note | T1/2 | Plasma Concentration | AUC | MRT | Clearance (CL) | Vd | Tmax | Bioavailability |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rat | 10 mg/kg | p.o. | SD Rats | 0.4 h | 1366.5 ng/mL | 771 ng·h/mL | 0.5 h | 2.5 L/h/kg | 1.4 L/kg | / | / |
| Rat | 2 mg/kg | i.v. | SD Rats | 2.2 h | 894 ng/mL | 1028.2 ng·h/mL | 1.7 h | / | / | 0.1 h | 26.7 % |
Chemical Information
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CAS No. 2640287-77-8
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Molecular Weight 515.65
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Formula C30H37N5O3
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SMILES
O=C1C2=CC(NC3CC4(C3)CN(C4)C(C)=O)=NC=C2C5(CN1C[C@@H](CN6CCC(C=CC=C7)=C7C6)O)CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PRMT5-IN-48 Related Classifications
HY-170792 Related Classifications
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