1. TGF-beta/Smad
  2. TGF-β Receptor
  3. Zilurgisertib

Zilurgisertib  (Synonyms: INCB-000928; NBU-928)

Cat. No.: HY-145608 Purity: 99.77%
COA Handling Instructions

Zilurgisertib (INCB-000928; NBU-928) is a selective ALK 2 inhibitor for researching diseases such as cancer.

For research use only. We do not sell to patients.

Zilurgisertib Chemical Structure

Zilurgisertib Chemical Structure

CAS No. : 2173389-57-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 863 In-stock
Solution
10 mM * 1 mL in DMSO USD 863 In-stock
Solid
1 mg USD 280 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2580 In-stock
50 mg USD 4000 In-stock
100 mg USD 6400 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Zilurgisertib (INCB-000928; NBU-928) is a selective ALK 2 inhibitor for researching diseases such as cancer.

IC50 & Target[1]

ALK2

 

Clinical Trial
Molecular Weight

502.65

Formula

C30H38N4O3

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC(C2=CC=C(C=C2)[C@]3(CN(C4CCOCC4)C5)[C@]5([H])C3)=CN=C1N)NC(CC6)(CC7)CCC67O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9895 mL 9.9473 mL 19.8946 mL
5 mM 0.3979 mL 1.9895 mL 3.9789 mL
10 mM 0.1989 mL 0.9947 mL 1.9895 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Zilurgisertib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Zilurgisertib
Cat. No.:
HY-145608
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