2276680-91-0
2276680-91-0
Chemical Structure
T-518
- CAS No.: 2276680-91-0
- Formula:C19H16F7N5O3
- Molecular Weight:495.35
InChIKey: OTPOPNFYEGYICX-ZYHUDNBSSA-N
SMILES: O=C(C(F)(F)C(F)(F)F)N[C@H]1[C@H](N2CC3=NC=C(C4=NN=C(C(F)F)O4)C=C3C2=O)CCCC1
Biological Activity: T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy[1][2].
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T-518 | 98.40% | T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy. | ||||||||||||||||||||
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References
- [1]. Onishi T, et al. A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice. Sci Rep. 2021 Jul 29;11(1):15423. [Content Brief]
- [2]. König B, et al. 2-(Difluoromethyl)-1, 3, 4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation?[J]. ACS Pharmacology & Translational Science, 2024.
