T-518
Based on 1 Customer Validation
T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy.
For research use only. We do not sell to patients.
- Purity : 98.40%
- CAS No.: 2276680-91-0
- Formula: C19H16F7N5O3
- Molecular Weight:495.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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hHDAC6 36 nM (IC50) |
In Vitro
T-518 inhibits human HDAC6 enzyme activity with IC50 of 36 nM (without pre-incubation) and 4.6 nM (after 60 min pre-incubation), but does not obviously inhibit HDAC1, 4, or 7[1].
T-518 (0.1-10 μM, 24 h) elevates tubulin acetylation significantly and dose-dependently in mouse primary neural cultures[1].
T-518 (3-30 μM, 24 h) does not increase histone H3 acetylation in mouse primary neural cultures [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
T-518 (300 mg/kg, p.o., one single dose) significantly elevates tubulin acetylation in WT mice but no effect on HDAC6 KO mice, suggesting the effect is dependent on HDAC6 inhibition[1].
T-518 (1-3 mg/kg, p.o., daily for 2 weeks) improves axonal transport in P301S tau Tg mice[1].
T-518 (1-3 mg/kg, p.o., daily for 3 months) decreases aging-dependent accumulation of tau in the FA fraction in mouse hippocampus without affecting the RAB-soluble and RIPA-soluble fractions[1].
T-518 (1-3 mg/kg, p.o., 2 w) ameliorates the novel object recognition deficit observed in vehicle-treated Tg mice compared to WT mice dose-dependently[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2276680-91-0
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Appearance Solid
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Molecular Weight 495.35
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Formula C19H16F7N5O3
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Color White to off-white
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SMILES
O=C(C(F)(F)C(F)(F)F)N[C@H]1[C@H](N2CC3=NC=C(C4=NN=C(C(F)F)O4)C=C3C2=O)CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T-518 Related Classifications
HY-161307 Related Classifications
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