T-518
Based on 1 Customer Validation
T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy.
For research use only. We do not sell to patients.
- Purity: 98.40%
- CAS No.: 2276680-91-0
- Formula: C19H16F7N5O3
- Molecular Weight:495.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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hHDAC6 36 nM (IC50) |
T-518 inhibits human HDAC6 enzyme activity with IC50 of 36 nM (without pre-incubation) and 4.6 nM (after 60 min pre-incubation), but does not obviously inhibit HDAC1, 4, or 7[1].
T-518 (0.1-10 μM, 24 h) elevates tubulin acetylation significantly and dose-dependently in mouse primary neural cultures[1].
T-518 (3-30 μM, 24 h) does not increase histone H3 acetylation in mouse primary neural cultures [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
T-518 (300 mg/kg, p.o., one single dose) significantly elevates tubulin acetylation in WT mice but no effect on HDAC6 KO mice, suggesting the effect is dependent on HDAC6 inhibition[1].
T-518 (1-3 mg/kg, p.o., daily for 2 weeks) improves axonal transport in P301S tau Tg mice[1].
T-518 (1-3 mg/kg, p.o., daily for 3 months) decreases aging-dependent accumulation of tau in the FA fraction in mouse hippocampus without affecting the RAB-soluble and RIPA-soluble fractions[1].
T-518 (1-3 mg/kg, p.o., 2 w) ameliorates the novel object recognition deficit observed in vehicle-treated Tg mice compared to WT mice dose-dependently[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2276680-91-0
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Appearance Solid
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Molecular Weight 495.35
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Formula C19H16F7N5O3
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Color White to off-white
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SMILES
O=C(C(F)(F)C(F)(F)F)N[C@H]1[C@H](N2CC3=NC=C(C4=NN=C(C(F)F)O4)C=C3C2=O)CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)