2387570-00-3
Chemical Structure
DZD1516
- CAS No.: 2387570-00-3
- Formula:C28H27F2N7O3
- Molecular Weight:547.56
InChIKey: IDQNCHCNBVCUHC-DEOSSOPVSA-N
SMILES: COC1=CC2=C(C(NC3=CC=C(C(C)=C3)OC4=CC5=NC=NN5C=C4)=NC=N2)C(O[C@H]6CCN(CC6(F)F)C)=C1
Biological Activity: DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1].
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DZD1516 | 99.62% | DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models. | ||||||||||||||||||||
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Keywords