2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HER2-IN-14

HER2-IN-14 (Compound 34) is an HER2 inhibitor with an IC50 of 18 nM. HER2-IN-14 also inhibits wt-EGFR with an IC50 of 6.3 μM.

For research use only. We do not sell to patients.

HER2-IN-14 Chemical Structure

HER2-IN-14 Chemical Structure

CAS No. : 2414056-35-0

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Other Forms of HER2-IN-14:

HER2-IN-14 Related Antibodies

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Description

HER2-IN-14 (Compound 34) is an HER2 inhibitor with an IC50 of 18 nM. HER2-IN-14 also inhibits wt-EGFR with an IC50 of 6.3 μM[1].

IC50 & Target[1]

HER2

18 nM (IC50)

EGFR (WT)

6.3 μM (IC50)

Molecular Weight

568.96

Formula

C26H23ClF2N8O3
CAS No.
SMILES

ClC(C=C1NC2=NC=NC3=C2C(O[C@@H]4C(F)(CN(CC4)C)F)=C(OC)C=C3)=C(C=C1)OC5=CC6=NC=NN6C=N5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HER2-IN-14 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HER2-IN-142414056-35-0EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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HER2-IN-14
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HY-153557A
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