2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. DZD1516

DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models.

For research use only. We do not sell to patients.

DZD1516 Chemical Structure

DZD1516 Chemical Structure

CAS No. : 2387570-00-3

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Based on 1 publication(s) in Google Scholar

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DZD1516 Related Antibodies

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Description

DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1].

IC50 & Target

HER2
Clinical Trial
Molecular Weight

547.56

Formula

C28H27F2N7O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=CC2=C(C(NC3=CC=C(C(C)=C3)OC4=CC5=NC=NN5C=C4)=NC=N2)C(O[C@H]6CCN(CC6(F)F)C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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DZD1516 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DZD15162387570-00-3DZD 1516DZD-1516EGFREpidermal growth factor receptorErbB-1HER1selectivegood blood-brain permeabilityantitumorCNSsubcutaneous xenograft mouse modelsInhibitorinhibitorinhibit

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