23979-41-1
23979-41-1
Chemical Structure
l-Naproxen
Synonym(s): (R)-Naproxen
- CAS No.: 23979-41-1
- Formula:C14H14O3
- Molecular Weight:230.26
IUPAC Name: (R)-2-(6-methoxynaphthalen-2-yl)propanoic acid
InChIKey: CMWTZPSULFXXJA-SECBINFHSA-N
SMILES: COC1=CC=C2C(C=CC([C@H](C(O)=O)C)=C2)=C1
Biological Activity: l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID)[1][2][3].
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l-Naproxen | 99.47% | l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID). | ||||||||||||||||||||
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l-Naproxen (Standard) | ≥98% | l-Naproxen (Standard) is the analytical standard of l-Naproxen. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780. [Content Brief]
- [2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103. [Content Brief]
- [3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182. [Content Brief]
