247044-77-5
Chemical Structure
TBC3486
- CAS No.: 247044-77-5
- Formula:C27H31N3O6S2
- Molecular Weight:557.68
IUPAC Name: (S)-3-(benzo[d][1,3]dioxol-5-yl)-3-(3-((S)-1-(bis(thiophen-2-ylmethyl)amino)-1-oxohexan-2-yl)ureido)propanoic acid
InChIKey: DWNIDSJEAZSEJG-VXKWHMMOSA-N
SMILES: [C@H](NC(N[C@H](C(N(CC1=CC=CS1)CC2=CC=CS2)=O)CCCC)=O)(CC(O)=O)C=3C=C4C(=CC3)OCO4
Biological Activity: TBC3486 is a highly selective integrin α4β1 inhibitor. TBC3486 acts as a chemosensitizer to enhance the sensitivity of leukemia cells to chemotherapy. TBC3486 exhibits efficacy in preclinical models of integrin α4-dependent inflammatory and autoimmune diseases, including a mouse model of autoimmune encephalomyelitis. TBC3486 can be used for the research of precursor B-cell acute lymphoblastic leukemia[1].
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TBC3486 | TBC3486 is a highly selective integrin α4β1 inhibitor. TBC3486 acts as a chemosensitizer to enhance the sensitivity of leukemia cells to chemotherapy. TBC3486 exhibits efficacy in preclinical models of integrin α4-dependent inflammatory and autoimmune diseases, including a mouse model of autoimmune encephalomyelitis. TBC3486 can be used for the research of precursor B-cell acute lymphoblastic leukemia. | |||||||||||||||||||||
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Keywords
