247079-84-1
247079-84-1
Chemical Structure
Iperoxo
- CAS No.: 247079-84-1
- Formula:C10H17IN2O2
- Molecular Weight:324.16
IUPAC Name: 4-((4,5-dihydroisoxazol-3-yl)oxy)-N,N,N-trimethylbut-2-yn-1-aminium iodide
InChIKey: XWEOIAMCTHLJJB-UHFFFAOYSA-M
SMILES: C[N+](C)(C)CC#CCOC1=NOCC1.[I-]
Biological Activity: Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR) that activates M1, M2 and M3 receptors with pEC50 of 9.87, 10.1 and 9.78. Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors when labeled with tritium[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Iperoxo | 99.48% | Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR) that activates M1, M2 and M3 receptors with pEC50 of 9.87, 10.1 and 9.78. Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors when labeled with tritium. | ||||||||||||||||||||
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References
- [1]. Schrage R, et, al. Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70. [Content Brief]
- [2]. Schrage R, et, al. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 2014 Aug 1;90(3):307-19. [Content Brief]
Keywords
