27003-73-2
Chemical Structure
Lariciresinol
- CAS No.: 27003-73-2
- Formula:C20H24O6
- Molecular Weight:360.40
IUPAC Name: 4-((2S,3R,4R)-4-(4-hydroxy-3-methoxybenzyl)-3-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methoxyphenol
InChIKey: MHXCIKYXNYCMHY-AUSJPIAWSA-N
SMILES: OC[C@@H]1[C@](C(C=C2)=CC(OC)=C2O)([H])OC[C@@H]1CC(C=C3)=CC(OC)=C3O
Biological Activity: Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 μM; Ki of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lariciresinol | 99.46% | Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 μM; Ki of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity. | ||||||||||||||||||||
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References
- [1]. Nakatsubo T, et al. Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis. J Biol Chem. 2008;283(23):15550-15557. [Content Brief]
- [2]. Ma ZJ, et al. Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway. Eur J Pharmacol. 2018 Feb 15;821:1-10. [Content Brief]
- [3]. Soltani M, et al. Investigating the cytotoxic effect of pinoresinol and lariciresinol on breast cancer cell line SKBr3. Modares Journal of Biotechnology, 2020, 11(1): 13-20.
- [4]. Sun Y, et al. Lariciresinol Induces Apoptosis and Inhibits Migration-Invasion of Patient-Derived Hypertrophic Scar Fibroblasts via Preventing Accumulation of Collagen. Revista Brasileira de Farmacognosia, 2024, 34(5): 1024-1031.
- [5]. Hwang B, et al. Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans. Biochem Biophys Res Commun. 2011 Jul 8;410(3):489-93. [Content Brief]
- [6]. Alam MB, et al. Lariciresinol Displays Anti-Diabetic Activity through Inhibition of α-Glucosidase and Activation and Enhancement of Insulin Signaling. Mol Nutr Food Res. 2022 Jul;66(13):e2100751. [Content Brief]
- [7]. Zhao X, et al. Lariciresinol protects rats from complete Freund's adjuvant induced arthritis in rats via modulation of transforming growth factor-β and nuclear factor kappa B pathway: An in vivo and in silico study. Chem Biol Drug Des. 2023 Jul;102(1):168-176. [Content Brief]
- [8]. Saarinen NM, et al. Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. Int J Cancer. 2008 Sep 1;123(5):1196-204. [Content Brief]
