2728520-90-7
Chemical Structure
WNK2-IN-1
- CAS No.: 2728520-90-7
- Formula:C19H20F6N4O
- Molecular Weight:434.38
InChIKey: XKRZDOXEEKNGQW-UHFFFAOYSA-N
SMILES: OCC1N(C2=NC=NC(N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)=C2)CCC1
Biological Activity: WNK2-IN-1 is a WNK2 inhibitor. WNK2-IN-1 inhibits the kinase activity of recombinant WNK2 in a dose-dependent manner, and simultaneously partially inhibits WNK3 and WNK4. WNK2-IN-1 modulates WNK2-SPAK downstream signaling by inhibiting WNK2-mediated SPAK phosphorylation, and further suppresses the proinflammatory transcriptional response induced by IL1β. WNK2-IN-1 can be used in studies related to the WNK2 signaling pathway and osteoarthritis[1].
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WNK2-IN-1 | WNK2-IN-1 is a WNK2 inhibitor. WNK2-IN-1 inhibits the kinase activity of recombinant WNK2 in a dose-dependent manner, and simultaneously partially inhibits WNK3 and WNK4. WNK2-IN-1 modulates WNK2-SPAK downstream signaling by inhibiting WNK2-mediated SPAK phosphorylation, and further suppresses the proinflammatory transcriptional response induced by IL1β. WNK2-IN-1 can be used in studies related to the WNK2 signaling pathway and osteoarthritis. | |||||||||||||||||||||
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