WNK2
WNK2 is the brain-enriched member of the WNK chloride-sensing kinase family and is expressed predominantly in neurons of the cortex, hippocampus and cerebellum. Like WNK1, it can activate the SPAK/OSR1 module that phosphorylates sodium-chloride cotransporters, but its physiological emphasis appears neural rather than renal. WNK2 sits within a chromosomal region frequently altered in glioma, and reduced WNK2 expression has been reported in tumor samples, prompting its proposal as a negative regulator of proliferation. Disease-causing WNK2 mutations also occur in some pseudohypoaldosteronism type II families. Because WNK2 is the least studied WNK in the brain, recombinant WNK2 aids neuronal ion-homeostasis research.
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WNK2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
