2743336-70-9
2743336-70-9
Chemical Structure
mHTT-IN-2
- CAS No.: 2743336-70-9
- Formula:C20H22FN7O
- Molecular Weight:395.43
InChIKey: VPWHAEPYJSEFEH-CQSZACIVSA-N
SMILES: FC1=CC(NC(C2=NC=C(N3C[C@@H](CC3)NC4CC4)N=C2)=O)=CN5C1=NC(C)=C5
Biological Activity: mHTT-IN-2 (compound 27) is a potent inhibitor (EC50=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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mHTT-IN-2 | 99.35% | mHTT-IN-2 (compound 27) is a potent inhibitor (EC50=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy. | ||||||||||||||||||||
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